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Efficacy

To date, over 1,000 women have participated in clinical trials with Promensil Menopause. All studies were conducted by specialists in universities and teaching hospitals under strict ethical approval using Good Clinical Research Practise guidelines.

Promensil Menopause has been clinically tested and studies show that Promensil's red clover isoflavones have the potential to:

  • Help manage the symptoms of menopause 1-4
  • Help relieve hot flushes
  • Help relieve night sweats
  • May help reduce bone loss in lumber spine 5
  • May help maintain cardiovascular health.6
  • Increase superficial cells in the vagina; an indicator for reducing vaginal atrophy.7
In addition, Promensil Menopause clinical trials have investigated safety parameters. The results of these trials were:
  • No increase in breast density. 8
  • No increase in endometrial thickening.9,10
  • No change in biochemical and haematological parameters 11 (including liver function) 9 .
  • Promensil is well-tolerated in healthy women. 59
More detail on Promensil safety studies can be found under Safety and Tolerability

Clinical Trials conducted with Promensil
The following papers have been published in peer-reviewed journals, or presented at scientific conferences:

Menopause Symptoms

Panay.57 Maturitas 57 (2007); 90-94. Integrating phytoestrogens with prescription medicines – A conservative clinical approach to vasomotor symptom management

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Thompson Coon J, Pittler MH, Ernst E Phytomedicine 2007
14:153-9 		Trifolium Pratense isoflavones in the treatment of menopausal hot flushes: A systematic review and meta-analysis. » Request a Reprint
Howes LG, Howes JB and Knight DC 53 Maturitas 2006
In Press 		Isoflavone Therapy for menopausal flushes: A systematic review and meta-analysis. » Request a Reprint
Hidalgo LA et al. 55 Gynecol Endocrinol
2005 21(5):257-64		 The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: A randomised, double-blind, placebo-controlled study. » Request a Reprint
Van de Weijer, P and Barentsen, R 2 Maturitas 2002; 42 (3): 187-193. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared to placebo.

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Jeri, A 1 The Female Patient 2002; 27:35-37. The use of an isoflavones supplement to relieve hot flushes.

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Nachtigall LB, et al. 3 The Female Patient 1999; 24:45-50. Nonprescription alternatives to hormone replacement therapy » Request a Reprint
Baber R et al. 10 Climacteric 1999; 2:85-92. Randomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women.

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Knight D, Howes J, and Eden J. 11 Climacteric 1999; 2: 79-84 The effect of Promensil, an isoflavone extract, on menopausal symptoms. » Request a Reprint
Tice et al. 12 JAMA. 2003 Jul 9;290(2):207-14 Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. » Request a Reprint
Atkinson C, Warren RML, Sala E, Dowsett M, Dunning AM, Healey CS, Runswick S, Day NE, Bingham SA. 8 Research 2004; 6:R170-R179. Red clover-derived isoflavones and mammographic breast density: a double blind, randomised, placebo-controlled trial. Breast Cancer » Request a Reprint
Hale GE, Hughes CL, Robboy SJ, Agarwal SK, and Bievre M. 9 Menopause 2001; 8 (5): 338-46. A double-blind randomized study on the effects of red clover isoflavones on the endometrium. » Request a Reprint


Bone Effects

Atkinson C et al. 5 Am J Clin Nutr 79 (2): 326-33. The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial

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In Vitro Study: Muir M, Siva D, Dai D, Mason R. 13 Presented at Australasian Menopause Society Meeting, Sydney, 2002. Isoflavones enhance human osteoblast proliferation, activity and lifespan in vitro » Request an Abstract


Cardiovascular Effects
Jeri A. 6 Presented at the 10th World Congress on the Menopause, Berlin, 2002. Effects of isoflavone phytoestrogens on lipid profile in postmenopausal Peruvian women » Request an Abstract
Nestel P et al. 14 J Clin Endocrinol Metab 1999. 84(3): 895-898 Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women

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Knudson Schult T et al. 15 Maturitas 2004 48
(3):209-18		 Effect of isoflavones on lipids and bone turnover markers in menopausal women. » Request a Reprint


Vaginal Effects
Woods R et al. 7 Journal of the British Menopause Society 2003. S2: 23. Effects of red clover isoflavones (Promensil) versus placebo on uterine endometrium, vaginal maturation index and the uterine artery in healthy postmenopausal women » Request an Abstract


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